The sixth season of the Tamil Nadu Premier League 2022 will commence on June 23 while the final of the tournament will be played on 31st July.
There will be a total of 32 matches in the tournament. The season will kick off when reigning champions Chepauk Super Gillies will lock horns against Nellai Royal Kings at Tirunelveli on Thursday.
The 32 matches will take place across four venues – Tirunelveli, Coimbatore, Salem, and Dindigul. The finale clash will be played at SNR College Cricket Ground, Coimbatore.
| Sr. No. | Date | Time (IST) | Fixture | Venue |
| 01 | 23 June 2022 | 07:15 PM | Chepauk Super Gillies vs Nellai Royal Kings | Tirunelveli |
| 02 | 24 June 2022 | 07:15 PM | Dindigul Dragons vs Ruby Trichy Warriors | Tirunelveli |
| 03 | 25 June 2022 | 03:15 PM | Siechem Madurai Panthers vs Chepauk Super Gillies | Tirunelveli |
| 04 | 25 June 2022 | 07:15 PM | Salem Spartans vs Nellai Royal Kings | Tirunelveli |
| 05 | 26 June 2022 | 07:15 PM | LYCA Kovai Kings vs Dindigul Dragons | Tirunelveli |
| 06 | 27 June 2022 | 07:15 PM | Ruby Trichy Warriors vs iDream Tiruppur Tamizhans | Tirunelveli |
| 07 | 30 June 2022 | 03:15 PM | Nellai Royal Kings vs Dindigul Dragons | Dindigul |
| 08 | 30 June 2022 | 07:15 PM | Siechem Madurai Panthers vs LYCA Kovai Kings | Dindigul |
| 09 | 04 July 2022 | 07:15 PM | iDream Tiruppur Tamizhans vs Dindigul Dragons | Dindigul |
| 10 | 05 July 2022 | 07:15 PM | Siechem Madurai Panthers vs Nellai Royal Kings | Dindigul |
| 11 | 06 July 2022 | 03:15 PM | LYCA Kovai Kings vs Salem Spartans | Dindigul |
| 12 | 06 July 2022 | 07:15 PM | Ruby Trichy Warriors vs Chepauk Super Gillies | Dindigul |
| 13 | 07 July 2022 | 07:15 PM | Dindigul Dragons vs Siechem Madurai Panthers | Dindigul |
| 14 | 10 July 2022 | 03:15 PM | Nellai Royal Kings vs iDream Tiruppur Tamizhans | Coimbatore |
| 15 | 10 July 2022 | 07:15 PM | Ruby Trichy Warriors vs LYCA Kovai Kings | Coimbatore |
| 16 | 11 July 2022 | 07:15 PM | Salem Spartans vs Siechem Madurai Panthers | Coimbatore |
| 17 | 12 July 2022 | 07:15 PM | Chepauk Super Gillies vs LYCA Kovai Kings | Coimbatore |
| 18 | 13 July 2022 | 07:15 PM | iDream Tiruppur Tamizhans vs Salem Spartans | Coimbatore |
| 19 | 15 July 2022 | 07:15 PM | Nellai Royal Kings vs Ruby Trichy Warriors | Coimbatore |
| 20 | 16 July 2022 | 03:15 PM | LYCA Kovai Kings vs iDream Tiruppur Tamizhans | Coimbatore |
| 21 | 16 July 2022 | 07:15 PM | Chepauk Super Gillies vs Dindigul Dragons | Coimbatore |
| 22 | 19 July 2022 | 07:15 PM | Salem Spartans vs Chepauk Super Gillies | Salem |
| 23 | 20 July 2022 | 07:15 PM | iDream Tiruppur Tamizhans vs Siechem Madurai Panthers | Salem |
| 24 | 21 July 2022 | 07:15 PM | Salem Spartans vs Ruby Trichy Warriors | Salem |
| 25 | 22 July 2022 | 07:15 PM | Chepauk Super Gillies vs iDream Tiruppur Tamizhans | Salem |
| 26 | 23 July 2022 | 07:15 PM | LYCA Kovai Kings vs Nellai Royal Kings | Salem |
| 27 | 24 July 2022 | 03:15 PM | Siechem Madurai Panthers vs Ruby Trichy Warriors | Salem |
| 28 | 24 July 2022 | 07:15 PM | Dindigul Dragons vs Salem Spartans | Salem |
| 29 | 26 July 2022 | 07:15 PM | Eliminator | Salem |
| 30 | 27 July 2022 | 07:15 PM | Qualifier 1 | Salem |
| 31 | 29 July 2022 | 07:15 PM | Qualifier 2 | Coimbatore |
| 32 | 31 July 2022 | 07:15 PM | TNPL 2022 final | Coimbatore |
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